DALBY man Simon Peter Wylie is fighting for his life in hospital after a horrific high-speed crash near Oakey Wednesday morning.

The 19-year-old was travelling east along the Warrego Highway towards Oakey when his white Honda Accord veered into the path of road-train travelling in the opposite direction.

Emergency Services were called to the crash two kilometres west of Oakey shortly after 11.20am.

Such was the force of the crash that debris was strewn over a 200 metre section of the highway.

Witnesses to the crash said the road-train literally ran over the front of Mr Wylie's vehicle.

It took emergency services personnel more than two hours to free Mr Wylie from his vehicle using hydraulic cutting equipment.

The crash closed the Warrego Highway in both directions for more than three hours.

The EMQ Rescue Helicopter was forced to land in the middle of the highway before transporting Mr Wylie to the Royal Brisbane Hospital in Brisbane.

Mr Wylie sustained serious and significant injuries to both his arms, legs, pelvis and torso.

Queensland Fire and Rescue Area Commander Paul Evans said he was amazed Mr Wylie survived the horrific crash.

"He is one very fortunate young man. I have seen a lot lesser crashes that have resulted in fatalities," Mr Evans said.

"Due to the significant nature of his injuries, it was an extremely delicate and difficult extrication.

"It is definitely one of the worst crashes we have seen recently," he said.

A Queensland Police spokesman said the nature of the crash suggested Mr Wylie could have been using a mobile phone and was momentarily distracted shortly before the crash.

"It is certainly something that police will be investigating," he said.

A spokesman for the Royal Brisbane Hospital said late Wednesday that Mr Wylie underwent emergency surgery and remains in a critical but stable condition in the hospital's intensive care unit.